In April 2011, car painter Jassim Al Shehab disappeared after his arrest by members of the Military Intelligence Division at a checkpoint in the Homs Governorate. Since then, his family has not been able to obtain any official information on his whereabouts. Given these facts, Alkarama and Human Rights Guardians wrote to the United Nations Working Group on Enforced Disappearances (WGEID) on 1 December 2015, hoping that it will help shed light on his fate.

In late December 2014, Hamrein Hussein, a 15-year-old Syrian Kurdish student from Amuda, was abducted on her way to school by a patrol of the People's Protection Units (YPG) – Syrian Kurdistan's armed forces – and forcibly enrolled. Seized of her case by her family, Alkarama and Human Rights Guardians referred it to the Independent International Commission of Inquiry on the Syrian Arab Republic (CoI Syria) on 2 December 2015.

On 25 November 2015, Alkarama wrote to several United Nations Special Procedures to encourage them to request a visit to Syria in order to raise the issues of enforced disappearance, torture and arbitrary detention. In particular, Alkarama wrote to the UN Working Group on Enforced Disappearances (WGEID), the UN Working Group on Arbitrary Detention (WGAD) and the UN Special Rapporteur on Torture (SRT) − all Special Procedures of the UN Human Rights Council − to engage directly with the competent authorities in Syria with a view to visiting to detention centres in the country.

In October 2012, Fadhil Othman, a 31-year-old concierge from Qamishli – a city in north-eastern Syria on the border with Turkey – disappeared from the national hospital where he was being treated after being shot by members of the Military Security at a checkpoint. Missing since, Alkarama and Human Rights Guardians wrote to the UN Working Group on Enforced Disappearances (WGEID) on 26 November 2015, hoping it will lead to the clarification of his fate and whereabouts.