On 6 October 2015, Alkarama and Human Rights Guardians sent a communication to the United Nations Working Group on Enforced or Involuntary Disappearances (WGEID) regarding the case of 23-year-old Mahmoud Ali Deeb and 32-year-old Mohannad Al Kheir, who disappeared in the town of Al-Haffah in the Latakia Governorate between 2012 and 2013.

On 5 October 2015, Alkarama sent an urgent appeal to the United Nations Working Group on Enforced or Involuntary Disappearances (WGEID) regarding the case of Syrian activist Bassel Khartabil, who disappeared after his transfer from Adra Prison on 3 October 2015.

On 24 August 2015, Alkarama and Human Rights Guardians sent a communication to the United Nations Working Group on Enforced or Involuntary Disappearances (WGEID) regarding the case of Nasrallah Al Moazzin, who disappeared following his abduction by members of the Air Forces Intelligence on 25 May 2013 in the Idlib countryside.

On 9 September 2015, Alkarama and Human Rights Guardians sent a communication to the United Nations Working Group on Enforced or Involuntary Disappearances (WGEID) regarding the disappearance of 22-year-old, Khalid Ali Deeb and his 34-year-old cousin, Mohammad Ali Deeb, after their respective arrests at checkpoints in Latakia and Al Bayda in November 2011 and May 2013.