On 10 June 2012, Ayed Al Ghashim, a peaceful activist during the Syrian uprisings, was arrested while crossing a checkpoint near Qamishli. He was only released a year later after being severely tortured while secretly detained. Concerned over this fact, on 9 August 2016, Alkarama and Human Rights Guardians submitted his case to the United Nations Special Rapporteur on Torture (SRT), Juan EMéndez E. Méndez.

On 5 July 2016, Ammar Al Hasan was released from Al Malikiyah detention centre – one of the central Kurdish prisons in north-eastern Syria – from where he disappeared in March 2015. During his secret detention, he was tortured in order to force him to confess to being a member of a terrorist group.

 On 11 May 2011, Ahmad Hassoun, a 19-year-old Syrian activist, was arrested by military officers at a checkpoint situated near the police station in his hometown of Bidama, northern Syria. One year after his arrest, his father collected his corpse bearing severe marks of torture at the Tishreen military hospital in Damascus. Concerned over Ahmad's death in detention, Alkarama and Human Rights Guardians sent his case to the Special Rapporteur on summary executions (SR SUMEX), Agnes Callamard.

On 26 July 2016, Alkarama sent an urgent appeal to the United Nations Working Group on Enforced Disappearances (WGEID) regarding the case of a Syrian citizen from the village of Al-Hashimiyah in the Hama Governorate who disappeared in Homs on 20 June 2015, after an arrest conducted by the Air Force Intelligence at a checkpoint. His family visited him once in Sednaya prison in late April 2016 but remains since without any information about his fate, fearing for his life as he suffers from a heart condition.

On 20 June 2015, Souhail Al Ashkar, a 44 year-old construction worker, was arrested, without a warrant,