On 23 September 2015, Alkarama sent an urgent appeal to the United Nations Working Group on Enforced or Involuntary Disappearances (WGEID), regarding the respective abductions of Taalat Hosni Quranu Ali Al Sharkawy and Abdelrahman Mohammed Abdelbasser by the Homeland Security and the Central Security Forces in August and September 2015. The authorities have been unresponsive to their families' inquiries, who fear that they could be tortured or ill-treated while being secretly detained.

On 22 September, Alkarama sent a communication to the United Nations Special Rapporteur on torture and other cruel, inhuman or degrading treatment or punishment (SRT) regarding the case of Ahmed Raafat Al Sayed Ali , a 20-year-old student who was arrested by the General Investigations in May 2014. Repeatedly tortured in detention, Ahmed was sentenced to three years in prison in July 2014 and has been since detained in Wadi El Natrun prison where he still faces ill-treatment and has been denied the right to see a doctor.

On 17 September 2015, Alkarama sent an urgent appeal to the United Nations Special Rapporteur on the Independence of Judges and Lawyers (SRIJL) regarding the arrest and detention of the head of the legal team defending nearly 500 individuals sentenced in Egypt's biggest mass trial of civilians before a military court. 54-year-old lawyer, Abdelmaksoud Ahmed Abdelmaksoud El Damanhoury was arrested by the Homeland Security in Damanhour in September 2015. Detained inside a Central Security Forces Camp since, he is accused under trumped-up charges and is at high risk of torture in retaliation for his work.

On 11 September 2015, Alkarama sent an urgent appeal to the United Nations Working Group on Enforced or Involuntary Disappearances (WGEID) regarding the case of sales director Hosni Talaat Mohammed Al Nagar, detained incommunicado since his arrest by the 10th of Ramadan Homeland Security in July 2015. Hosni, who already suffers from diabetes, was severely tortured to make him confess to crimes he had not committed, before he was charged with "affiliation to a terrorist cell linked to the Muslim Brotherhood" and of various acts of sabotage.

On 2 September 2015, Alkarama sent an urgent appeal to the United Nations Working Group on Enforced or Involuntary Disappearances (WGEID) regarding the cases of 20-year-old student, Abdelrahman Attef Hussein and 31-year-old employee Hani Said Kahla, both disappeared since their respective arrests by the police on 11 July and 19 August 2015. Despite the testimonies of witnesses to their arrests, and the numerous steps taken by their families to find them, the authorities continue to deny their disappearances. Secretly detained, they are at high risk of torture, a widespread practice in Egypt, particularly against real and alleged political opponents, but also against students.

On 28 August 2015, Alkarama sent an urgent appeal to the United Nations Working Group on Enforced and Involuntary Disappearances (WGEID) regarding the abduction of Mohamed Abdelaziz Farag, 54, his 18-year-old son, Abdelaziz Mohammed Abdelaziz Farag, and his 61-year-old brother, Ismael Abdelaziz Farag. All disappeared following their abduction, from their home in Shubra, by the Homeland Security on 23 August 2015. Threatened twice by Homeland Security officers since the abduction of their three relatives, the Farag family has stopped looking for them but fear that they will be tortured during their secret detention.

On 3 September 2015, Alkarama sent an urgent appeal to the United Nations Working Group on Enforced or Involuntary Disappearances (WGEID) regarding the enforced disappearance of journalist and member of the Muslim Brotherhood, Mosab Abdalla Abdelhamid Morsy Hamed, in early July 2015. This journalist from Egyptian satellite opposition news channel Misr Alaan TV went missing following his abduction, by the Homeland Security, from his family home in the city of Tanta, 100km north of Cairo. Despite the strong media coverage of his abduction and the numerous steps taken by his relatives to locate him, Mosab has not been seen in the past two months. Given his work and political affiliation, he is at high risk of torture during his secret detention.

On 16 August 2015, the Egyptian authorities enacted a controversial anti-terrorism law (Arabic version online) in spite of numerous international and local calls against it. Alkarama had sent a letter to different United Nations Special Procedures on 7 July 2015, including to the Special Rapporteur on the promotion and protection of human rights and fundamental freedoms while countering terrorism (SRCT) asking them to call upon the Egyptian authorities to refrain from adopting such a law.

On 7 August 2015, Alkarama sent an urgent appeal to the United Nations Working Group on Enforced Disappearances (WGEID) regarding the disappearances of Mohamed Taha Ahmed Ouahdan, Mohammad Mehani Hassan Moussa and Mohamed Saad Aleoua Al Sayed, arrested between 28 May 2015 and 19 June 2015. Although the three men were indicted by the Military Prosecution of East Cairo, and despite reports of their detention in Tora prison, the authorities continue to deny their detention.

On 5 August, Alkarama sent an urgent appeal to the United Nations Working Group on Enforced or Involuntary Disappearances (WGEID) regarding the disappearances of Mahmoud Saleh Mohammed Ali and Hassan Saleh Ahmed Mohammed respectively arrested by Egyptian security and police forces on 7 June and 5 July 2015. Both are at high risk of torture in retaliation for their alleged political affiliations or with the aim to force them confess to crimes that they did not commit, as is often the case in Egypt. Meanwhile, the authorities continue to deny their detentions.