On 8 July 2016, Alkarama referred to the United Nations Special Rapporteur on the Right to Health (SRH) the case of Mahmoud Hassan Sabry, who was arrested on 29 July 2015 in Cairo by Egyptian Homeland Security Forces and thrown from his apartment's balcony for allegedly having participated to "violent demonstrations", causing him severe body injuries and a partial paralysis. Detained ever since, he is denied access to adequate medical care and his life remains at risk, despite his family's appeals and attempts at soliciting the intervention of local authorities.

On 28 June 2016, after more than a year of arbitrary detention and exposure to torture, eight young women were liberated from Port-Said prison after their acquittal by Damietta Criminal Court in Egypt, while two others remain detained to date.

On 24 June 2016, Alkarama sent a report to the Sub Committee on Accreditation (SCA) of the International Coordinating Committee of National Institutions for the Promotion and Protection of Human Rights (ICC-NHRI) in view of its review of Egypt's National Council for Human Rights (NCHR) at its next session in November 2016. Recalling that the NCHR had not been reviewed since 2006, Alkarama stressed that it had not been able to independently and impartially promote and protect human rights in Egypt and it therefore invited the Sub-Committee to downgrade the NCHR from status A to B to mark its non-compliance with international standards.

On 25 May 2016, Hany Mohamed Hassanin Sharaf, founder of the Civilized Alternative Party and former Egyptian Air Force pilot, was released from jail after spending more than six months in arbitrary detention. Prosecuted under trumped-up charges that were triggered by his political activism and in particular his work on the creation of a new opposition party, Hany was facing death penalty in case of a trial before a military court. Alkarama had solicited the United Nations Working Group on Arbitrary Detention (WGAD) in November 2015, to ask the Egyptian authorities to release him.