On 25 November 2015, Alkarama wrote to several United Nations Special Procedures to encourage them to request a visit to Syria in order to raise the issues of enforced disappearance, torture and arbitrary detention. In particular, Alkarama wrote to the UN Working Group on Enforced Disappearances (WGEID), the UN Working Group on Arbitrary Detention (WGAD) and the UN Special Rapporteur on Torture (SRT) − all Special Procedures of the UN Human Rights Council − to engage directly with the competent authorities in Syria with a view to visiting to detention centres in the country.

On 28 April 2015, following an urgent appeal sent by Alkarama on 8 January 2015, the United Nations Working Group on Arbitrary Detention (WGAD) issued an Opinion regarding the detention of 16-year-old Egyptian high school student, Ahmed Mahmoud Mahmoud Taha Mahmoud as arbitrary and requesting "the Government of Egypt to release the minor immediately and provide him with an enforceable right to reparation." If Ahmed Mahmoud was released on bail on 18 April 2015, he is still under investigation and at risk of being arrested again. In view of the present case together with previously adopted opinions related to Egypt, the WGAD also expressed "a grave concern" regarding the "systemic and widespread practice of arbitrary detentions of young individuals" in the country. According to Alkarama Egypt's researcher, at least 3,200 children have been arrested and detained since the July 2013 military coup, many of whom were also tortured and ill-treated or detained with adults.