On 15 July 2016, Alkarama referred to the United Nations Working Group on Arbitrary Detention (WGAD) the case of Omar Mabrouk, a young student currently detained in Giza, Cairo, and facing an unfair trial. Held in incommunicado detention since his unlawful extradition from Kuwait to Egypt in October 2015 and until April 2016, he was severely tortured to confess crimes he never committed. He was then charged with "establishment of an unlawful group" for having criticized the Egyptian Government through social networks and put on trial while denied the possibility to prepare his defence.

On 8 July 2016, Alkarama referred to the United Nations Special Rapporteur on the Right to Health (SRH) the case of Mahmoud Hassan Sabry, who was arrested on 29 July 2015 in Cairo by Egyptian Homeland Security Forces and thrown from his apartment's balcony for allegedly having participated to "violent demonstrations", causing him severe body injuries and a partial paralysis. Detained ever since, he is denied access to adequate medical care and his life remains at risk, despite his family's appeals and attempts at soliciting the intervention of local authorities.

On 28 June 2016, after more than a year of arbitrary detention and exposure to torture, eight young women were liberated from Port-Said prison after their acquittal by Damietta Criminal Court in Egypt, while two others remain detained to date.

On 24 June 2016, Alkarama sent a report to the Sub Committee on Accreditation (SCA) of the International Coordinating Committee of National Institutions for the Promotion and Protection of Human Rights (ICC-NHRI) in view of its review of Egypt's National Council for Human Rights (NCHR) at its next session in November 2016. Recalling that the NCHR had not been reviewed since 2006, Alkarama stressed that it had not been able to independently and impartially promote and protect human rights in Egypt and it therefore invited the Sub-Committee to downgrade the NCHR from status A to B to mark its non-compliance with international standards.