On 24 November 2015, Alkarama sent an urgent appeal to the United Nations Working Group on Enforced of Involuntary Disappearances (WGEID) regarding the arrest by the Homeland Security of 45-year-old former Egyptian Air Force pilot Hany Mohamed Hassanin Sharaf on 18 November 2015. Disappeared since, his family believes that his arrest was triggered by his intention of creating an opposition political party, the Civilized Alternative Party and fears that he could be tortured while in secret detention in retaliation for his political affiliations.

On 19 November 2015, Alkarama sent two communications, one to the United Nations Special Rapporteur on Torture and other cruel, inhuman or degrading treatment or punishment (SRT) and one to the UN Working Group on Enforced Disappearances (WGEID), regarding the case of 20-year-old Egyptian student Omar Abdulrahman Ahmed Youssef Mabrouk, who was extradited to Egypt, where he is at high risk of torture and trial by a military tribunal, on 2 November 2015. Before Omar's extradition, Alkarama had sent an urgent appeal to the SRT, requesting him to urge Kuwaiti authorities to reject Egypt's request for extradition and to release him immediately.

Alkarama's report documents hundreds of cases of death in detention resulting from torture, denial of medical care and poor conditions of detention.

Less than two weeks after the Egyptian authorities adopted a new law giving prison personnel the right to torture and ill-treat prisoners while restricting even further the rights of Egyptian detainees, Alkarama publishes a new report that documents 323 cases of death that occurred in Egyptian detention facilities between August 2013 and September 2015 as a direct consequence of torture, ill-treatment or denial of medical care. All result from widespread and systematic violations of Egypt's international obligations. The report investigates the causes of these deaths and suggests a way to put an end to this worsening situation by providing effective recommendations to the Egyptian authorities and the international community.

On 27 October 2015, Alkarama sent an urgent appeal to the United Nations Special Rapporteur on Torture (SRT) regarding the arrests, in September 2015, of Magdy Ahmed Abdelmoaty El Husseini and his son Ahmed Magdy Ahmed Abdelmoaty El Husseini, by the General Investigations Services. Secretly detained for five days, the two men reported having been repeatedly tortured by officers before being charged with "affiliation to a banned group" by the public prosecutor and brought back to Nasr City police station where they remain detained to date and at high risk of torture and ill-treatment.

On 26 October 2015, Alkarama sent a letter to the United Nations Working Group on Arbitrary Detention (WGAD) and the Special Rapporteur on Torture (SRT) regarding the adoption by the Egyptian authorities of new restrictive amendments to Law n°396 of 1956 on Prisons Regulations. While the rights of prisoners in Egypt were already insufficiently protected under the previous law, President Abdel Fattah El Sisi puts them even more in jeopardy by enacting law n°105 of 2015. These amendments give prison personnel the right to torture and ill-treat prisoners, while restricting the rights of their relatives and providing new penalties against detainees.

On 15 October 2015, Alkarama sent a communication to the United Nations Working Group on Arbitrary Detention (WGAD) regarding the case of 29-year-old journalist Mohamed Salahaddin Madani Mahmoud, arrested in March 2014, secretly detained and tortured in the aim of making him confess to crimes, and referred to the Alexandria Military Court that sentenced him to 7 years in prison.

On 24 September 2015, Alkarama sent an urgent appeal to the United Nations Special Rapporteur on torture and other cruel, inhuman or degrading treatment or punishment (SRT) regarding the arrest of 32-year-old freelance journalist Hassan Mahmoud Ragab El Kabany in January 2015. Reportedly tortured on numerous occasions, including in September, El Kabany has not been brought before a judge in his eight-month detention, has been denied any form of medical care and remains at high risk of ill-treatment in Tora high security prison.

On 24 September 2015, Alkarama sent an urgent appeal to the United Nations Working Group on Enforced or Involuntary Disappearances (WGEID) regarding the disappearance of 17-year-old Khaled Mohamed El Beltagy following his abduction by the Security Forces on 22 September 2015. The son of Mohamed El Beltagy, Secretary General of the Freedom and Justice Party − the political wing of the Muslim Brotherhood − Khaled is at high risk of being tortured again during his secret detention, for the second time in less than a year.