On 20 July 2015, Alkarama sent an urgent appeal to the United Nations Working Group on Enforced or Involuntary Disappearances (WGEID) regarding the case of Mahmoud Tawfik Abdalaal, a 55-year-old former parliamentarian of the Freedom and Justice Party (FJP) – the political wing of the Muslim Brotherhood – disappeared since his arrest on 6 June 2015. Diagnosed with cirrhosis and Hepatitis C prior to his arrest, he is unlikely to be granted the medical care his health requires during his secret detention by the Homeland Security. Because of his political affiliations he is also at high risk of torture, a widespread practice in Egypt against real and alleged political opponents.

On 15 July 2015, Alkarama informed the United Nations Special Rapporteur on the promotion and protection of the right to freedom of opinion and expression (SR FRDX) of the expulsion, by the Egyptian authorities, of a 22-year-old French student, Fanny Ohier. On 3 July 2015, Fanny was sent back to France in retaliation for her academic research that focused, among other things, on the 6 April Youth Movement, an activist group of "70,000 mostly young and educated Egyptians", whose members are constantly harassed and subjected to arbitrary arrests by the authorities since the 2011 revolution.

On 28 April 2015, following an urgent appeal sent by Alkarama on 8 January 2015, the United Nations Working Group on Arbitrary Detention (WGAD) issued an Opinion regarding the detention of 16-year-old Egyptian high school student, Ahmed Mahmoud Mahmoud Taha Mahmoud as arbitrary and requesting "the Government of Egypt to release the minor immediately and provide him with an enforceable right to reparation." If Ahmed Mahmoud was released on bail on 18 April 2015, he is still under investigation and at risk of being arrested again. In view of the present case together with previously adopted opinions related to Egypt, the WGAD also expressed "a grave concern" regarding the "systemic and widespread practice of arbitrary detentions of young individuals" in the country. According to Alkarama Egypt's researcher, at least 3,200 children have been arrested and detained since the July 2013 military coup, many of whom were also tortured and ill-treated or detained with adults.

On 10 July 2015, Alkarama sent an urgent appeal to the United Nations Working Group on Enforced of Involuntary Disappearances (WGEID) regarding the disappearances of four young men who disappeared following their abduction by members of the police and the army between 22 April and 28 May 2015. Worried that they will be subjected to torture or ill-treatment in secret detention inside a Homeland Security facility or one of its affiliated centres, and following numerous unsuccessful attempts to shed light on their fate at the local or national level, their families contacted Alkarama to raise their respective cases with the UN.