On 3 November 2016, Alkarama alerted the United Nations Working Group on Enforced or Involuntary Disappearances (WGEID) of the case of Qadry Samy Zaky Abd Elrahman Muafy, a 49-year-old Egyptian citizen from Kafr Saad, Damietta Governorate who was abducted by members of the Police in Mit Ghamr, Dakahlia Governorate on 29 October 2016.

In late August 2016, the United Nations Working Group on Arbitrary Detention (WGAD), a group of independent experts, adopted Opinion n°42/2016; in which they qualify the detention of Ahmed Yousry Zaky, an Egyptian student who was arrested on 5 May 2015, as "arbitrary". After having reviewed the communication sent by Alkarama on 11 May 2016, and faced with the lack of answer from the Egyptian Government, the UN experts ruled that the Egyptian authorities was violating the student's fundamental rights and consequently called upon them to immediately release him. Importantly, the Opinion further manifests the Working Group's concern over a pattern of arbitrary detention in the country.

On 25 October 2016, Alkarama solicited the urgent intervention of the UN Working Group on Arbitrary Detention (WGAD) with regards to the final sentencing to 20 years in prison of former President Mohamed Morsi and other members of his staff, as a result of an Egyptian Court of Cassation's ruling on 22 October 2016.

On 19 October 2016, Alkarama referred to the United Nations Special Rapporteur on the Right to Health (SRH) the case of Ali Ahmed Ali Kerata, a 53-year-old employee who was arrested on 19 August 2014 in Damietta by members of the police forces falling under the Egyptian Ministry of Interior. Detained in the central police station of Damietta, Kerata is suffering from life-threatening health issues and is denied access to adequate medical care. His health continues to aggravate and his family fears that his life is at risk should he not be provided with immediate and appropriate medical care.